ACELLULAR CEMENTUM PDF

BSP is multifunctional, affecting cell attachment and signaling through an RGD integrin-binding region, and acting as a positive regulator for mineral precipitation by nucleating hydroxyapatite crystals. BSP is present in cementum, the hard tissue covering the tooth root that anchors periodontal ligament PDL attachment. Results collected here suggest that BSP plays a non-redundant role in acellular cementum formation, likely involved in initiating mineralization on the root surface. Through its importance to cementum integrity, BSP is essential for periodontal function. Keywords: bone sialoprotein, cementum, periodontal ligament, bone, alkaline phosphatase, extracellular matrix Introduction Bone sialoprotein BSP, or integrin binding sialoprotein is an extracellular matrix protein in the Small Integrin Binding Ligand N-linked Glycoprotein SIBLING family, associated with mineralized tissues of the skeleton and dentition Ganss et al.

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BSP is multifunctional, affecting cell attachment and signaling through an RGD integrin-binding region, and acting as a positive regulator for mineral precipitation by nucleating hydroxyapatite crystals. BSP is present in cementum, the hard tissue covering the tooth root that anchors periodontal ligament PDL attachment.

Results collected here suggest that BSP plays a non-redundant role in acellular cementum formation, likely involved in initiating mineralization on the root surface. Through its importance to cementum integrity, BSP is essential for periodontal function. Keywords: bone sialoprotein, cementum, periodontal ligament, bone, alkaline phosphatase, extracellular matrix Introduction Bone sialoprotein BSP, or integrin binding sialoprotein is an extracellular matrix protein in the Small Integrin Binding Ligand N-linked Glycoprotein SIBLING family, associated with mineralized tissues of the skeleton and dentition Ganss et al.

The ability of BSP to act as a positive regulator of hydroxyapatite precipitation has been demonstrated in vitro Hunter and Goldberg, and is of particular interest in terms of regulating mineralized tissue development. In addition to its inclusion in bone extracellular matrix, BSP is present in both acellular and cellular cementum MacNeil et al.

Acellular cementum is the thin, mineralized tissue covering the cervical portion of the tooth root, important for attachment of the periodontal ligament PDL to the root surface Bosshardt, ; Foster et al. Cellular cementum is a more bone-like tissue covering apical portions of roots. Developmental factors directing cementogenesis remain poorly defined, hampering progress toward more effective therapies for cementum regeneration.

The finding that BSP was present in cementum and strongly expressed by cementoblasts led to speculation that this protein might contribute to cementum formation and mineralization Somerman et al. Here, we analyzed the function of BSP in cementogenesis and periodontal stability by determining the effects of the lack of BSP on tooth formation.

From 3 to 6 animals were analyzed per genotype at ages 14, 26, 30, and 60 post-natal days dpn. For SEM analysis, extracted and cleansed molars were osmium-coated. Histomorphometry was used to quantify cementum, root-lining cells, and epithelial attachment, and statistical analysis was performed by independent-samples t test. IHC used biotinylated secondary antibodies and peroxidase substrate.

BSP protein is localized to alveolar bone and to acellular and cellular cementum covering the cervical and apical portions of the molar, respectively Figs.

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Central Role of Pyrophosphate in Acellular Cementum Formation

Structure[ edit ] Cementum situated around a human molar The cells of cementum are the entrapped cementoblasts, the cementocytes. Each cementocyte lies in its lacuna , similar to the pattern noted in bone. These lacunae also have canaliculi or canals. Unlike those in bone, however, these canals in cementum do not contain nerves, nor do they radiate outward. Instead, the canals are oriented toward the periodontal ligament and contain cementocytic processes that exist to diffuse nutrients from the ligament because it is vascularized. After the apposition of cementum in layers, the cementoblasts that do not become entrapped in cementum line up along the cemental surface along the length of the outer covering of the periodontal ligament.

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